The MidSouth Conference was formed in 1965. The newly formed league began with seven original members who would compete during that initial football season in the fall.

         

MidSouth Conference Champions
1980	Dexter	1972
1979		1971	Dexter
1978	Mount Olive	1970	New Hebron
1977	New Hebron	1969
1976	Dexter	1968
1975	Mount Olive	1967	Mize
1974	Mount Olive	1966
1973		1965	New Hebron