| 1A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Maplesville 55-8 R.C. Hatch | | |
| 11/4/2022 (Fri) | | Leroy 47-12 Georgiana | | |
| 11/4/2022 (Fri) | | Linden 54-8 Autaugaville | | |
| 11/4/2022 (Fri) | | Brantley 39-3 Choctaw County | | |
| 11/4/2022 (Fri) | | Elba 42-20 Southern Choctaw | | |
| 11/4/2022 (Fri) | | Sweet Water 48-8 Verbena | | |
| 11/4/2022 (Fri) | | Millry 55-7 Florala | | |
| 11/4/2022 (Fri) | | Loachapoka 28-24 Keith | | |
| 11/4/2022 (Fri) | | Meek 46-6 Cedar Bluff | | |
| 11/4/2022 (Fri) | | Pickens County 34-15 Wadley | | |
| 11/4/2022 (Fri) | | Valley Head 61-20 Phillips Bear Creek | | |
| 11/4/2022 (Fri) | | Marion County 59-22 Ragland | | |
| 11/4/2022 (Fri) | | Spring Garden 35-7 South Lamar | | |
| 11/4/2022 (Fri) | | Coosa Christian 51-8 Hackleburg | | |
| 11/4/2022 (Fri) | | Lynn 42-0 Donoho | | |
| 11/4/2022 (Fri) | | Addison 66-22 Appalachian | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Leroy 33-8 Maplesville | | |
| 11/11/2022 (Fri) | | Brantley 41-20 Linden | | |
| 11/11/2022 (Fri) | | Sweet Water 27-20 Elba | | |
| 11/10/2022 (Thu) | | Millry 63-12 Loachapoka | | |
| 11/11/2022 (Fri) | | Pickens County 44-36 Meek | | |
| 11/11/2022 (Fri) | | Marion County 27-6 Valley Head | | |
| 11/11/2022 (Fri) | | Coosa Christian 31-28 Spring Garden | | |
| 11/11/2022 (Fri) | | Lynn 41-14 Addison | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Leroy 42-14 Brantley | | |
| 11/18/2022 (Fri) | | Millry 41-6 Sweet Water | | |
| 11/18/2022 (Fri) | | Pickens County 40-14 Marion County | | |
| 11/18/2022 (Fri) | | Coosa Christian 46-29 Lynn | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Leroy 28-11 Millry | | |
| 11/25/2022 (Fri) | | Pickens County 44-40 Coosa Christian | | |
| Championship Game |
| 12/1/2022 (Thu) | | Leroy 42-20 Pickens County | | Auburn |
| 2A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | B.B. Comer 45-20 Lanett | | |
| 11/4/2022 (Fri) | | Wicksburg 34-7 J.U. Blacksher | | |
| 11/4/2022 (Fri) | | Reeltown 49-6 Thorsby | | |
| 11/4/2022 (Fri) | | G.W. Long 19-16 St. Lukes | | |
| 11/4/2022 (Fri) | | Ariton 61-22 Chickasaw | | |
| 11/4/2022 (Fri) | | Highland Home 29-21 Isabella | | |
| 11/4/2022 (Fri) | | Clarke County 27-7 Cottonwood | | |
| 11/4/2022 (Fri) | | Vincent 36-35 Luverne | | |
| 11/4/2022 (Fri) | | Lexington 49-14 North Sand Mountain | | |
| 11/4/2022 (Fri) | | Tuscaloosa Academy 42-28 Locust Fork | | |
| 11/4/2022 (Fri) | | Fyffe 55-8 Red Bay | | |
| 11/4/2022 (Fri) | | Winston County 50-14 Cleveland | | |
| 11/4/2022 (Fri) | | Southeastern 16-7 Lamar County | | |
| 11/4/2022 (Fri) | | Pisgah 40-20 Hatton | | |
| 11/4/2022 (Fri) | | Aliceville 62-13 West End Walnut Grove | | |
| 11/4/2022 (Fri) | | Falkville 42-7 Collinsville | | |
| 2nd Round |
| 11/11/2022 (Fri) | | B.B. Comer 22-14 Wicksburg | | |
| 11/11/2022 (Fri) | | Reeltown 55-0 G.W. Long | | |
| 11/11/2022 (Fri) | | Highland Home 44-28 Ariton | | |
| 11/11/2022 (Fri) | | Clarke County 43-28 Vincent | | |
| 11/11/2022 (Fri) | | Tuscaloosa Academy 23-20 Lexington | | |
| 11/11/2022 (Fri) | | Fyffe 35-6 Winston County | | |
| 11/11/2022 (Fri) | | Pisgah 48-28 Southeastern | | |
| 11/11/2022 (Fri) | | Aliceville 38-21 Falkville | | |
| 3rd Round |
| 11/18/2022 (Fri) | | B.B. Comer 28-22 Reeltown | | |
| 11/18/2022 (Fri) | | Highland Home 19-0 Clarke County | | |
| 11/18/2022 (Fri) | | Fyffe 35-7 Tuscaloosa Academy | | |
| 11/18/2022 (Fri) | | Pisgah 26-22 Aliceville | | |
| Semi-finals |
| 11/25/2022 (Fri) | | B.B. Comer 44-15 Highland Home | | |
| 11/25/2022 (Fri) | | Fyffe 41-14 Pisgah | | |
| Championship Game |
| 12/1/2022 (Thu) | | Fyffe 40-28 B.B. Comer | | Auburn |
| 3A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Dadeville 33-8 Southside Selma | | |
| 11/4/2022 (Fri) | | Thomasville 20-9 Straughn | | |
| 11/4/2022 (Fri) | | St. James 54-7 Walter Wellborn | | |
| 11/4/2022 (Fri) | | W.S. Neal 27-13 Opp | | |
| 11/4/2022 (Fri) | | Mobile Christian 30-3 Houston Academy | | |
| 11/4/2022 (Fri) | | Trinity 37-0 Saks | | |
| 11/4/2022 (Fri) | | Pike County 42-14 Excel | | |
| 11/4/2022 (Fri) | | Alabama Christian 63-30 Randolph County | | |
| 11/4/2022 (Fri) | | Mars Hill 62-7 Danville | | |
| 11/4/2022 (Fri) | | Geraldine 24-8 Winfield | | |
| 11/4/2022 (Fri) | | Madison Academy 49-28 Phil Campbell | | |
| 11/4/2022 (Fri) | | Sylvania 35-6 Fayette County | | |
| 11/4/2022 (Fri) | | Piedmont 61-0 Oakman | | |
| 11/4/2022 (Fri) | | Colbert County 57-28 J.B. Pennington | | |
| 11/4/2022 (Fri) | | Gordo 50-6 Ohatchee | | |
| 11/4/2022 (Fri) | | Lauderdale County 41-7 Vinemont | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Thomasville 15-14 Dadeville | OT | |
| 11/11/2022 (Fri) | | St. James 42-21 W.S. Neal | | |
| 11/11/2022 (Fri) | | Mobile Christian 27-13 Trinity | | |
| 11/11/2022 (Fri) | | Pike County 41-39 Alabama Christian | | |
| 11/11/2022 (Fri) | | Geraldine 17-14 Mars Hill | | |
| 11/11/2022 (Fri) | | Sylvania 48-45 Madison Academy | OT | |
| 11/11/2022 (Fri) | | Piedmont 42-20 Colbert County | | |
| 11/11/2022 (Fri) | | Gordo 44-14 Lauderdale County | | |
| 3rd Round |
| 11/18/2022 (Fri) | | St. James 40-15 Thomasville | | |
| 11/18/2022 (Fri) | | Mobile Christian 27-7 Pike County | | |
| 11/18/2022 (Fri) | | Sylvania 27-7 Geraldine | | |
| 11/18/2022 (Fri) | | Piedmont 27-14 Gordo | | |
| Semi-finals |
| 11/25/2022 (Fri) | | St. James 35-7 Mobile Christian | | |
| 11/25/2022 (Fri) | | Piedmont 55-22 Sylvania | | |
| Championship Game |
| 12/1/2022 (Thu) | | St. James 45-28 Piedmont | | Auburn |
| 4A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Anniston 52-0 Sipsey Valley | | |
| 11/4/2022 (Fri) | | B.T. Washington 46-43 Orange Beach | | |
| 11/4/2022 (Fri) | | American Christian 16-13 Munford | | |
| 11/4/2022 (Fri) | | Andalusia 25-10 Jackson | | |
| 11/4/2022 (Fri) | | Catholic Montgomery 41-13 Bayside Academy | | |
| 11/4/2022 (Fri) | | Jacksonville 35-28 Bibb County | | |
| 11/4/2022 (Fri) | | T.R. Miller 41-13 Montgomery Academy | | |
| 11/4/2022 (Fri) | | Handley 46-6 West Blocton | | |
| 11/4/2022 (Fri) | | Priceville 49-28 Central Florence | | |
| 11/4/2022 (Fri) | | Oneonta 56-14 Haleyville | | |
| 11/4/2022 (Fri) | | Deshler 68-34 Madison County | | |
| 11/4/2022 (Fri) | | Etowah 42-21 Northside | | |
| 11/4/2022 (Fri) | | Cherokee County 47-10 Corner | | |
| 11/4/2022 (Fri) | | West Morgan 27-7 Westminster Christian | | |
| 11/4/2022 (Fri) | | Dora 34-6 Good Hope | | |
| 11/4/2022 (Fri) | | Randolph 54-15 Rogers | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Anniston 38-20 B.T. Washington | | |
| 11/11/2022 (Fri) | | Andalusia 31-7 American Christian | | |
| 11/11/2022 (Fri) | | Catholic Montgomery 44-27 Jacksonville | | |
| 11/11/2022 (Fri) | | Handley 27-14 T.R. Miller | | |
| 11/11/2022 (Fri) | | Oneonta 34-20 Priceville | | |
| 11/11/2022 (Fri) | | Deshler 36-33 Etowah | | |
| 11/11/2022 (Fri) | | Cherokee County 42-28 West Morgan | | |
| 11/11/2022 (Fri) | | Randolph 47-37 Dora | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Andalusia 35-28 Anniston | | |
| 11/18/2022 (Fri) | | Catholic Montgomery 21-14 Handley | | |
| 11/18/2022 (Fri) | | Oneonta 62-21 Deshler | | |
| 11/18/2022 (Fri) | | Cherokee County 35-21 Randolph | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Andalusia 29-26 Catholic Montgomery | | |
| 11/25/2022 (Fri) | | Cherokee County 42-21 Oneonta | | |
| Championship Game |
| 12/1/2022 (Thu) | | Andalusia 28-7 Cherokee County | | Auburn |
| 5A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Central Clay County 50-0 Holtville | | |
| 11/4/2022 (Fri) | | Gulf Shores 42-10 Carroll | | |
| 11/4/2022 (Fri) | | Demopolis 48-28 Elmore County | | |
| 11/4/2022 (Fri) | | Faith Academy 21-15 Eufaula | | |
| 11/4/2022 (Fri) | | Charles Henderson 20-16 Williamson | | |
| 11/4/2022 (Fri) | | Tallassee 49-16 Selma | | |
| 11/4/2022 (Fri) | | UMS-Wright 56-13 Headland | | |
| 11/4/2022 (Fri) | | Beauregard 35-10 Marbury | | |
| 11/4/2022 (Fri) | | Russellville 63-10 Boaz | | |
| 11/4/2022 (Fri) | | Pleasant Grove 43-14 Alexandria | | |
| 11/4/2022 (Fri) | | Arab 54-14 East Limestone | | |
| 11/4/2022 (Fri) | | Moody 29-21 Jasper | | |
| 11/4/2022 (Fri) | | Leeds 34-13 Fairfield | | |
| 11/4/2022 (Fri) | | Scottsboro 45-14 Brewer | | |
| 11/4/2022 (Fri) | | Ramsay 61-25 Southside Gadsden | | |
| 11/4/2022 (Fri) | | Guntersville 24-13 Fairview | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Gulf Shores 26-21 Central Clay County | | |
| 11/11/2022 (Fri) | | Faith Academy 36-15 Demopolis | | |
| 11/11/2022 (Fri) | | Charles Henderson 34-7 Tallassee | | |
| 11/11/2022 (Fri) | | UMS-Wright 48-30 Beauregard | | |
| 11/11/2022 (Fri) | | Pleasant Grove 37-14 Russellville | | |
| 11/11/2022 (Fri) | | Arab 42-20 Moody | | |
| 11/11/2022 (Fri) | | Leeds 35-10 Scottsboro | | |
| 11/10/2022 (Thu) | | Ramsay 45-9 Guntersville | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Faith Academy 20-14 Gulf Shores | | |
| 11/18/2022 (Fri) | | Charles Henderson 19-16 UMS-Wright | | |
| 11/18/2022 (Fri) | | Pleasant Grove 41-38 Arab | | |
| 11/18/2022 (Fri) | | Ramsay 26-19 Leeds | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Charles Henderson 27-12 Faith Academy | | |
| 11/25/2022 (Fri) | | Ramsay 27-20 Pleasant Grove | | |
| Championship Game |
| 12/1/2022 (Thu) | | Ramsay 41-20 Charles Henderson | | Auburn |
| 6A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Hillcrest Tuscaloosa 38-0 Calera | | |
| 11/4/2022 (Fri) | | Saraland 48-14 Wetumpka | | |
| 11/4/2022 (Fri) | | Homewood 35-30 McAdory | | |
| 11/4/2022 (Fri) | | Pike Road 22-21 Spanish Fort | | |
| 11/4/2022 (Fri) | | St. Pauls 13-0 Carver Montgomery | | |
| 11/4/2022 (Fri) | | Pelham 44-14 Northridge | | |
| 11/4/2022 (Fri) | | Theodore 35-20 Sidney Lanier | | |
| 11/4/2022 (Fri) | | Hueytown 56-28 Benjamin Russell | | |
| 11/4/2022 (Fri) | | Gadsden City 41-24 Cullman | | |
| 11/4/2022 (Fri) | | Mountain Brook 49-7 Pinson Valley | | |
| 11/4/2022 (Fri) | | Hartselle 52-7 Buckhorn | | |
| 11/4/2022 (Fri) | | Center Point 26-8 Jackson-Olin | | |
| 11/4/2022 (Fri) | | Parker 7-6 Clay-Chalkville | | |
| 11/4/2022 (Fri) | | Muscle Shoals 58-7 Hazel Green | | |
| 11/4/2022 (Fri) | | Gardendale 31-14 Oxford | | |
| 11/4/2022 (Fri) | | Decatur 31-8 Fort Payne | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Saraland 56-31 Hillcrest Tuscaloosa | | |
| 11/11/2022 (Fri) | | Homewood 24-21 Pike Road | | |
| 11/11/2022 (Fri) | | St. Pauls 38-7 Pelham | | |
| 11/11/2022 (Fri) | | Theodore 29-18 Hueytown | | |
| 11/11/2022 (Fri) | | Mountain Brook 37-6 Gadsden City | | |
| 11/11/2022 (Fri) | | Hartselle 36-26 Center Point | | |
| 11/11/2022 (Fri) | | Muscle Shoals 31-6 Parker | | |
| 11/11/2022 (Fri) | | Gardendale 31-7 Decatur | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Saraland 57-56 Homewood | OT | |
| 11/18/2022 (Fri) | | Theodore 28-0 St. Pauls | | |
| 11/18/2022 (Fri) | | Mountain Brook 49-30 Hartselle | | |
| 11/18/2022 (Fri) | | Muscle Shoals 38-7 Gardendale | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Saraland 21-6 Theodore | | |
| 11/25/2022 (Fri) | | Mountain Brook 28-7 Muscle Shoals | | |
| Championship Game |
| 12/1/2022 (Thu) | | Saraland 38-17 Mountain Brook | | Auburn |
