| 1A Playoffs |
| 1st Round |
| 11/7/2025 (Fri) | | Biggersville 40-0 Ashland | | |
| 11/7/2025 (Fri) | | West Lowndes 7-0 Coffeeville | | |
| 11/7/2025 (Fri) | | Falkner 42-6 Thrasher | | |
| 11/7/2025 (Fri) | | Calhoun City 50-7 French Camp Academy | | |
| 11/7/2025 (Fri) | | Tupelo Christian Prep 58-6 Potts Camp | | |
| 11/7/2025 (Fri) | | Leflore County 44-8 Vardaman | | |
| 11/7/2025 (Fri) | | Byers 21-20 Smithville | | |
| 11/7/2025 (Fri) | | Nanih Waiya 50-28 West Bolivar | | |
| 11/7/2025 (Fri) | | Simmons 28-8 Noxapater | | |
| 11/7/2025 (Fri) | | Stringer 36-12 Mount Olive | | |
| 11/7/2025 (Fri) | | Bogue Chitto 40-32 Richton | | |
| 11/7/2025 (Fri) | | Leake County 34-0 Shaw | | |
| 11/7/2025 (Fri) | | Taylorsville 66-0 West Lincoln | | |
| 11/7/2025 (Fri) | | South Delta 28-6 Ethel | | |
| 11/7/2025 (Fri) | | Lumberton 60-18 Salem | | |
| 11/7/2025 (Fri) | | Okolona 24-20 West Tallahatchie | | |
| 2nd Round |
| 11/14/2025 (Fri) | | Okolona 40-20 Falkner | | |
| 11/14/2025 (Fri) | | Taylorsville 46-8 South Delta | | |
| 11/14/2025 (Fri) | | Biggersville 52-22 West Lowndes | | |
| 11/14/2025 (Fri) | | Calhoun City 53-14 Tupelo Christian Prep | | |
| 11/14/2025 (Fri) | | Leflore County 54-6 Byers | | |
| 11/14/2025 (Fri) | | Nanih Waiya 42-28 Lumberton | | |
| 11/14/2025 (Fri) | | Simmons 30-14 Stringer | | |
| 11/14/2025 (Fri) | | Leake County 36-8 Bogue Chitto | | |
| 3rd Round |
| 11/21/2025 (Fri) | | Calhoun City 30-6 Leflore County | | |
| 11/21/2025 (Fri) | | Biggersville 29-12 Okolona | | |
| 11/21/2025 (Fri) | | Simmons 20-8 Nanih Waiya | | |
| 11/21/2025 (Fri) | | Taylorsville 36-0 Leake County | | |
| Semi-finals |
| 11/28/2025 (Fri) | | Simmons 12-8 Taylorsville | | |
| 11/28/2025 (Fri) | | Calhoun City 36-14 Biggersville | | |
| Championship Game |
| 12/4/2025 (Thu) | | Calhoun City 14-8 Simmons | | |
| 2A Playoffs |
| 1st Round |
| 11/7/2025 (Fri) | | Water Valley 34-8 Walnut | | |
| 11/7/2025 (Fri) | | Hamilton 55-6 Strayhorn | | |
| 11/7/2025 (Fri) | | Clarkdale 20-16 Scott Central | | |
| 11/7/2025 (Fri) | | North Forest 41-20 Loyd Star | | |
| 11/7/2025 (Fri) | | East Marion 46-6 Wilkinson County | | |
| 11/7/2025 (Fri) | | Baldwyn 42-6 East Union | | |
| 11/7/2025 (Fri) | | Kemper County 38-6 George | | |
| 11/7/2025 (Fri) | | East Webster 53-0 Leland | | |
| 11/7/2025 (Fri) | | Amite County 36-19 Collins | | |
| 11/7/2025 (Fri) | | Wesson 49-14 Perry Central | | |
| 11/7/2025 (Fri) | | Mize 49-16 Lake | | |
| 11/7/2025 (Fri) | | Bay Springs 12-0 Pelahatchie | | |
| 11/7/2025 (Fri) | | Northside 42-0 Velma Jackson | | |
| 11/7/2025 (Fri) | | Charleston 44-25 Philadelphia | | |
| 11/7/2025 (Fri) | | Myrtle 29-6 Hatley | | |
| 11/7/2025 (Fri) | | Heidelberg 78-6 Newton | | |
| 2nd Round |
| 11/14/2025 (Fri) | | Kemper County 38-14 Water Valley | | |
| 11/14/2025 (Fri) | | Charleston 66-14 Hamilton | | |
| 11/14/2025 (Fri) | | Heidelberg 56-0 North Forest | | |
| 11/14/2025 (Fri) | | Clarkdale 12-8 Amite County | | |
| 11/14/2025 (Fri) | | East Marion 42-20 Bay Springs | | |
| 11/14/2025 (Fri) | | Northside 32-20 Baldwyn | | |
| 11/14/2025 (Fri) | | East Webster 57-0 Myrtle | | |
| 11/14/2025 (Fri) | | Mize 28-26 Wesson | | |
| 3rd Round |
| 11/21/2025 (Fri) | | Heidelberg 64-14 Clarkdale | | |
| 11/21/2025 (Fri) | | Kemper County 50-32 Northside | | |
| 11/21/2025 (Fri) | | East Webster 61-40 Charleston | | |
| 11/21/2025 (Fri) | | Mize 24-6 East Marion | | |
| Semi-finals |
| 11/28/2025 (Fri) | | Heidelberg 46-14 Mize | | |
| 11/28/2025 (Fri) | | East Webster 21-14 Kemper County | | |
| Championship Game |
| 12/6/2025 (Sat) | | East Webster 27-16 Heidelberg | | |
| 3A Playoffs |
| 1st Round |
| 11/7/2025 (Fri) | | Kossuth 49-8 Holly Springs | | |
| 11/7/2025 (Fri) | | Noxubee County 41-15 Yazoo County | | |
| 11/7/2025 (Fri) | | Winona 41-22 OBannon | | |
| 11/7/2025 (Fri) | | Hazlehurst 57-40 Tylertown | | |
| 11/7/2025 (Fri) | | Franklin County 42-6 Saint Patrick | | |
| 11/7/2025 (Fri) | | Seminary 35-0 Southeast Lauderdale | | |
| 11/7/2025 (Fri) | | Choctaw County 53-16 Thomas Edwards | | |
| 11/7/2025 (Fri) | | Coahoma County 50-7 Alcorn Central | | |
| 11/7/2025 (Fri) | | Aberdeen 42-34 Humphreys County | | |
| 11/7/2025 (Fri) | | Booneville 33-10 Independence | | |
| 11/7/2025 (Fri) | | Belmont 28-14 North Panola | | |
| 11/7/2025 (Fri) | | Union 33-27 Jefferson Davis County | | |
| 11/7/2025 (Fri) | | Presbyterian Christian 53-14 Jefferson County | | |
| 11/7/2025 (Fri) | | Magee 23-16 Quitman | | |
| 11/7/2025 (Fri) | | West Marion 42-12 Port Gibson | | |
| 11/7/2025 (Fri) | | Raleigh 44-0 Pisgah | | |
| 2nd Round |
| 11/14/2025 (Fri) | | Choctaw County 49-7 Kossuth | | |
| 11/14/2025 (Fri) | | Winona 21-8 Belmont | | |
| 11/14/2025 (Fri) | | Franklin County 23-20 Magee | | |
| 11/14/2025 (Fri) | | Noxubee County 35-8 Coahoma County | | |
| 11/14/2025 (Fri) | | Aberdeen 58-39 Booneville | | |
| 11/14/2025 (Fri) | | Raleigh 34-28 Presbyterian Christian | | |
| 11/14/2025 (Fri) | | Seminary 21-7 West Marion | | |
| 11/14/2025 (Fri) | | Union 48-21 Hazlehurst | | |
| 3rd Round |
| 11/21/2025 (Fri) | | Winona 42-20 Aberdeen | | |
| 11/21/2025 (Fri) | | Raleigh 35-21 Union | | |
| 11/21/2025 (Fri) | | Noxubee County 34-33 Choctaw County | | |
| 11/21/2025 (Fri) | | Seminary 15-3 Franklin County | | |
| Semi-finals |
| 11/28/2025 (Fri) | | Noxubee County 54-21 Choctaw County | | |
| 11/28/2025 (Fri) | | Raleigh 27-14 Seminary | | |
| Championship Game |
| 12/6/2025 (Sat) | | Raleigh 12-6 Noxubee County | | |
| 4A Playoffs |
| 1st Round |
| 11/7/2025 (Fri) | | Senatobia 35-8 Greenwood | | |
| 11/7/2025 (Fri) | | Clarksdale 30-6 Yazoo City | | |
| 11/7/2025 (Fri) | | New Albany 42-36 Shannon | | |
| 11/7/2025 (Fri) | | Forest 18-7 Choctaw Central | | |
| 11/7/2025 (Fri) | | Newton County 41-13 Mendenhall | | |
| 11/7/2025 (Fri) | | Itawamba AHS 42-23 Tishomingo County | | |
| 11/7/2025 (Fri) | | Leake Central 43-14 Richland | | |
| 11/7/2025 (Fri) | | Pass Christian 52-32 South Pike | | |
| 11/7/2025 (Fri) | | Corinth 40-0 Amory | | |
| 11/7/2025 (Fri) | | Kosciusko 58-10 Rosa Fort | | |
| 11/7/2025 (Fri) | | Houston 28-22 North Pontotoc | | |
| 11/7/2025 (Fri) | | Louisville 49-7 Ripley | | |
| 11/7/2025 (Fri) | | McComb 68-26 Greene County | | |
| 11/7/2025 (Fri) | | Poplarville 49-20 Forest County AHS | | |
| 11/7/2025 (Fri) | | Columbia 49-0 Moss Point | | |
| 11/7/2025 (Fri) | | Morton 35-14 West Lauderdale | | |
| 2nd Round |
| 11/14/2025 (Fri) | | Clarksdale 26-8 Houston | | |
| 11/14/2025 (Fri) | | Corinth 14-0 Senatobia | | |
| 11/14/2025 (Fri) | | Louisville 50-22 New Albany | | |
| 11/14/2025 (Fri) | | Poplarville 43-34 Forest | | |
| 11/14/2025 (Fri) | | Columbia 27-22 Newton County | | |
| 11/14/2025 (Fri) | | Kosciusko 40-14 Itawamba AHS | | |
| 11/14/2025 (Fri) | | McComb 41-40 Leake Central | | |
| 11/14/2025 (Fri) | | Pass Christian 49-22 Morton | | |
| 3rd Round |
| 11/21/2025 (Fri) | | Kosciusko 14-3 Corinth | | |
| 11/21/2025 (Fri) | | Poplarville 55-20 McComb | | |
| 11/21/2025 (Fri) | | Columbia 41-6 Pass Christian | | |
| 11/21/2025 (Fri) | | Louisville 34-16 Clarksdale | | |
| Semi-finals |
| 11/28/2025 (Fri) | | Columbia 20-14 Poplarville | | |
| 11/28/2025 (Fri) | | Kosciusko 17-7 Louisville | | |
| Championship Game |
| 12/5/2025 (Fri) | | Columbia 6-0 Kosciusko | | |
| 5A Playoffs |
| 1st Round |
| 11/14/2025 (Fri) | | West Point 42-19 Vicksburg | | |
| 11/14/2025 (Fri) | | Pontotoc 27-0 Lanier | | |
| 11/14/2025 (Fri) | | Cleveland Central 35-28 Lafayette | | |
| 11/14/2025 (Fri) | | Holmes County Central 36-28 New Hope | | |
| 11/14/2025 (Fri) | | Brookhaven 55-6 Northeast Jones | | |
| 11/14/2025 (Fri) | | Wayne County 34-10 South Jones | | |
| 11/14/2025 (Fri) | | Stone 35-7 Sumrall | | |
| 11/14/2025 (Fri) | | Laurel 39-3 Purvis | | |
| 2nd Round |
| 11/21/2025 (Fri) | | West Point 37-0 Pontotoc | | |
| 11/21/2025 (Fri) | | Holmes County Central 36-14 Cleveland Central | | |
| 11/21/2025 (Fri) | | Brookhaven 42-7 Wayne County | | |
| 11/21/2025 (Fri) | | Laurel 24-21 Stone | | |
| Semi-finals |
| 11/28/2025 (Fri) | | West Point 20-6 Holmes County Central | | |
| 11/28/2025 (Fri) | | Brookhaven 31-6 Laurel | | |
| Championship Game |
| 12/4/2025 (Thu) | | Brookhaven 31-19 West Point | | |
| 6A Playoffs |
| 1st Round |
| 11/14/2025 (Fri) | | Neshoba Central 28-27 South Panola | | |
| 11/14/2025 (Fri) | | Ridgeland 35-28 Grenada | | |
| 11/14/2025 (Fri) | | Warren Central 42-14 Center Hill | | |
| 11/14/2025 (Fri) | | Lake Cormorant 26-7 Callaway | | |
| 11/14/2025 (Fri) | | Hattiesburg 42-0 Pearl River Central | | |
| 11/14/2025 (Fri) | | Pascagoula 42-7 Terry | | |
| 11/14/2025 (Fri) | | Picayune 55-7 George County | | |
| 11/14/2025 (Fri) | | Hancock 21-14 West Jones | | |
| 2nd Round |
| 11/21/2025 (Fri) | | Neshoba Central 55-45 Ridgeland | | |
| 11/21/2025 (Fri) | | Warren Central 24-7 Lake Cormorant | | |
| 11/21/2025 (Fri) | | Hattiesburg 35-20 Pascagoula | | |
| 11/21/2025 (Fri) | | Picayune 52-20 Hancock | | |
| Semi-finals |
| 11/28/2025 (Fri) | | Warren Central 45-42 Ridgeland | | |
| 11/28/2025 (Fri) | | Hattiesburg 47-27 Picayune | | |
| Championship Game |
| 12/5/2025 (Fri) | | Warren Central 56-34 Hattiesburg | | |
| MAIS-1A-D1 Playoffs |
| 1st Round |
| 10/31/2025 (Fri) | | Sylva-Bay Academy 34-26 Porters Chapel Academy | | |
| 10/31/2025 (Fri) | | Claiborne LA 52-26 Delta Academy | | |
| 10/31/2025 (Fri) | | Deer Creek 46-6 Prentiss Christian | | |
| 10/31/2025 (Fri) | | Benton Academy 48-28 Delta Streets Academy | | |
| 2nd Round |
| 11/7/2025 (Fri) | | Newton County Academy 48-20 Claiborne LA | | |
| 11/7/2025 (Fri) | | River Oaks LA 40-34 Sylva-Bay Academy | OT | |
| 11/7/2025 (Fri) | | Humphreys Academy 46-14 Deer Creek | | |
| 11/7/2025 (Fri) | | Prairie View LA 39-20 Benton Academy | | |
| Semi-finals |
| 11/14/2025 (Fri) | | River Oaks LA 42-12 Newton County Academy | | |
| 11/14/2025 (Fri) | | Humphreys Academy 40-12 Prairie View LA | | |
| Championship Game |
| 11/21/2025 (Fri) | | River Oaks LA 20-8 Humphreys Academy | | |
| MAIS-1A-D2 Playoffs |
| 1st Round |
| 10/31/2025 (Fri) | | Calhoun Academy 46-12 Marvell AR | | |
| 10/31/2025 (Fri) | | Lee AR 52-6 Franklin LA | | |
| 10/31/2025 (Fri) | | Tunica Academy 38-0 Tensas LA | | |
| 10/31/2025 (Fri) | | Tallulah LA 50-14 Heritage Christian Academy | | |
| 2nd Round |
| 11/7/2025 (Fri) | | Calhoun Academy 40-26 Wilkinson Christian | | |
| 11/7/2025 (Fri) | | DeSoto AR 38-20 Lee AR | | |
| 11/7/2025 (Fri) | | Columbus Christian 58-14 Tunica Academy | | |
| 11/7/2025 (Fri) | | Tallulah LA 22-18 Briarfield LA | | |
| Semi-finals |
| 11/14/2025 (Fri) | | DeSoto AR 42-0 Calhoun Academy | | |
| 11/14/2025 (Fri) | | Tallulah LA 56-32 Columbus Christian | | |
| Championship Game |
| 11/21/2025 (Fri) | | DeSoto AR 34-12 Tallulah LA | | |
