| 1A Playoffs |
| 1st Round |
| 11/8/2024 (Fri) | | Baldwyn 49-0 Smithville | | |
| 11/8/2024 (Fri) | | Coffeeville 20-6 Byers | | |
| 11/8/2024 (Fri) | | Biggersville 56-16 Okolona | | |
| 11/8/2024 (Fri) | | Stringer 36-28 Noxapater | | |
| 11/8/2024 (Fri) | | Lumberton 42-12 Shaw | | |
| 11/8/2024 (Fri) | | East Marion 37-20 South Delta | | |
| 11/8/2024 (Fri) | | Vardaman 42-22 Thrasher | | |
| 11/8/2024 (Fri) | | West Lowndes 52-9 Tupelo Christian | | |
| 11/8/2024 (Fri) | | Taylorsville 46-0 Ethel | | |
| 11/8/2024 (Fri) | | West Tallahatchie 35-14 Sacred Heart | | |
| 11/8/2024 (Fri) | | Falkner 49-0 Potts Camp | | |
| 11/8/2024 (Fri) | | Strayhorn 35-0 Ashland | | |
| 11/8/2024 (Fri) | | Simmons 58-14 Enterprise Lincoln | | |
| 11/8/2024 (Fri) | | Nanih Waiya 28-6 Leake County | | |
| 11/8/2024 (Fri) | | Velma Jackson 62-6 Mount Olive | | |
| 2nd Round |
| 11/15/2024 (Fri) | | Simmons 46-8 Stringer | | |
| 11/15/2024 (Fri) | | Velma Jackson 42-12 West Tallahatchie | | |
| 11/15/2024 (Fri) | | Baldwyn 49-13 Falkner | | |
| 11/15/2024 (Fri) | | Myrtle 49-22 Biggersville | | |
| 11/15/2024 (Fri) | | Taylorsville 22-6 East Marion | | |
| 11/15/2024 (Fri) | | Vardaman 48-6 Coffeeville | | |
| 11/15/2024 (Fri) | | West Lowndes 40-14 Strayhorn | | |
| 11/15/2024 (Fri) | | Lumberton 27-0 Nanih Waiya | | |
| 3rd Round |
| 11/22/2024 (Fri) | | Baldwyn 29-7 Vardaman | | |
| 11/22/2024 (Fri) | | West Lowndes 46-12 Myrtle | | |
| 11/22/2024 (Fri) | | Velma Jackson 60-18 Taylorsville | | |
| 11/22/2024 (Fri) | | Simmons 22-18 Lumberton | | |
| Semi-finals |
| 11/29/2024 (Fri) | | Simmons 50-0 Velma Jackson | | |
| 11/29/2024 (Fri) | | Baldwyn 34-6 West Lowndes | | |
| Championship Game |
| 12/5/2024 (Thu) | | Baldwyn 21-20 Simmons | | |
| 2A Playoffs |
| 1st Round |
| 11/8/2024 (Fri) | | Bogue Chitto 34-12 Saint Andrews Episcopal | | |
| 11/8/2024 (Fri) | | Loyd Star 42-6 Pelahatchie | | |
| 11/8/2024 (Fri) | | Mize 54-12 Lake | | |
| 11/8/2024 (Fri) | | Raleigh 47-0 Wilkinson County | | |
| 11/8/2024 (Fri) | | Scott Central 40-18 Collins | | |
| 11/8/2024 (Fri) | | Union 55-28 Walnut | | |
| 11/8/2024 (Fri) | | Leflore County 36-6 Water Valley | | |
| 11/8/2024 (Fri) | | Eupora 38-20 Hamilton | | |
| 11/8/2024 (Fri) | | Philadelphia 44-3 Hatley | | |
| 11/8/2024 (Fri) | | Northside 56-0 Bruce | | |
| 11/8/2024 (Fri) | | Charleston 58-14 Palmer | | |
| 11/8/2024 (Fri) | | Sebastopol 42-21 East Union | | |
| 11/8/2024 (Fri) | | Calhoun City 38-0 Riverside | | |
| 11/8/2024 (Fri) | | Bay Springs 34-16 North Forrest | | |
| 11/8/2024 (Fri) | | Pisgah 51-20 Amite County | | |
| 11/8/2024 (Fri) | | Heidelberg 66-0 Clarkdale | | |
| 2nd Round |
| 11/15/2024 (Fri) | | Union 36-14 Leflore County | | |
| 11/15/2024 (Fri) | | Northside 26-6 Philadelphia | | |
| 11/15/2024 (Fri) | | Charleston 56-20 Sebastopol | | |
| 11/15/2024 (Fri) | | Calhoun City 38-0 Eupora | | |
| 11/15/2024 (Fri) | | Bay Springs 28-13 Pisgah | | |
| 11/15/2024 (Fri) | | Heidelberg 54-0 Bogue Chitto | | |
| 11/15/2024 (Fri) | | Loyd Star 38-32 Mize | | |
| 11/15/2024 (Fri) | | Raleigh 18-0 Scott Central | | |
| 3rd Round |
| 11/22/2024 (Fri) | | Northside 20-3 Union | | |
| 11/22/2024 (Fri) | | Charleston 30-12 Calhoun City | | |
| 11/22/2024 (Fri) | | Heidelberg 30-8 Bay Springs | | |
| 11/22/2024 (Fri) | | Raleigh 36-8 Loyd Star | | |
| Semi-finals |
| 11/29/2024 (Fri) | | Charleston 22-14 Northside | | |
| 11/29/2024 (Fri) | | Heidelberg 26-12 Raleigh | | |
| Championship Game |
| 12/5/2024 (Thu) | | Heidelberg 30-6 Charleston | | |
| 3A Playoffs |
| 1st Round |
| 11/8/2024 (Fri) | | Booneville 17-7 Mooreville | | |
| 11/8/2024 (Fri) | | Rosa Fort 44-37 Yazoo County | | |
| 11/8/2024 (Fri) | | Choctaw County 47-6 Mantachie | | |
| 11/8/2024 (Fri) | | Winona 35-0 Coahoma County | | |
| 11/8/2024 (Fri) | | Humphreys County 40-0 North Panola | | |
| 11/8/2024 (Fri) | | East Webster 47-6 Belmont | | |
| 11/8/2024 (Fri) | | Independence 21-20 Elzy | | |
| 11/8/2024 (Fri) | | Aberdeen 28-23 Kossuth | | |
| 11/8/2024 (Fri) | | Noxubee County 42-3 Saint Stanislaus | | |
| 11/8/2024 (Fri) | | Jefferson Davis County 46-26 Wesson | | |
| 11/8/2024 (Fri) | | West Marion 39-0 Southeast Lauderdale | | |
| 11/8/2024 (Fri) | | Seminary 20-12 South Pike | | |
| 11/8/2024 (Fri) | | Jefferson County 38-14 Hazlehurst | | |
| 11/8/2024 (Fri) | | Tylertown 18-17 Enterprise Clarke | | |
| 11/8/2024 (Fri) | | Magee 39-7 Franklin County | | |
| 11/8/2024 (Fri) | | Kemper County 41-22 Perry Central | | |
| 2nd Round |
| 11/15/2024 (Fri) | | Seminary 21-7 West Marion | | |
| 11/15/2024 (Fri) | | Choctaw County 41-27 Winona | | |
| 11/15/2024 (Fri) | | Noxubee County 31-6 Jefferson Davis County | | |
| 11/15/2024 (Fri) | | Jefferson County 38-20 Tylertown | | |
| 11/15/2024 (Fri) | | Magee 21-12 Kemper County | | |
| 11/15/2024 (Fri) | | Rosa Fort 22-0 Booneville | | |
| 11/15/2024 (Fri) | | East Webster 34-16 Humphreys County | | |
| 11/15/2024 (Fri) | | Aberdeen 44-28 Independence | | |
| 3rd Round |
| 11/22/2024 (Fri) | | East Webster 35-0 Aberdeen | | |
| 11/22/2024 (Fri) | | Choctaw County 37-0 Rosa Fort | | |
| 11/22/2024 (Fri) | | Noxubee County 45-15 Seminary | | |
| 11/22/2024 (Fri) | | Magee 12-6 Jefferson County | | |
| Semi-finals |
| 11/29/2024 (Fri) | | Noxubee County 36-24 Magee | | |
| 11/29/2024 (Fri) | | Choctaw County 41-20 East Webster | | |
| Championship Game |
| 12/5/2024 (Thu) | | Choctaw County 34-27 Noxubee County | | |
| 4A Playoffs |
| 1st Round |
| 11/8/2024 (Fri) | | Kosciusko 15-14 Senatobia | | |
| 11/8/2024 (Fri) | | Quitman 34-28 Greene County | | |
| 11/8/2024 (Fri) | | Amory 23-7 Newton County | | |
| 11/8/2024 (Fri) | | Forest 49-7 Bay | | |
| 11/8/2024 (Fri) | | Lanier 28-21 Sumrall | | |
| 11/8/2024 (Fri) | | Forrest County AHS 49-6 Raymond | | |
| 11/8/2024 (Fri) | | Columbia 55-3 Richland | | |
| 11/8/2024 (Fri) | | Poplarville 27-26 Mendenhall | | |
| 11/8/2024 (Fri) | | McComb 33-0 Lawrence County | | |
| 11/8/2024 (Fri) | | Northeast Jones 31-14 Pass Christian | | |
| 11/8/2024 (Fri) | | West Lauderdale 49-28 Ripley | | |
| 11/8/2024 (Fri) | | Houston 41-0 South Pontotoc | | |
| 11/8/2024 (Fri) | | Louisville 35-0 North Pontotoc | | |
| 11/8/2024 (Fri) | | New Albany 25-12 Greenwood | | |
| 11/8/2024 (Fri) | | Itawamba AHS 42-21 Choctaw Central | | |
| 11/8/2024 (Fri) | | Shannon 48-14 Leake Central | | |
| 2nd Round |
| 11/15/2024 (Fri) | | Shannon 29-20 Kosciusko | | |
| 11/15/2024 (Fri) | | McComb 42-9 Northeast Jones | | |
| 11/15/2024 (Fri) | | West Lauderdale 25-7 Houston | | |
| 11/15/2024 (Fri) | | Louisville 58-7 Amory | | |
| 11/15/2024 (Fri) | | Forest 23-20 Lanier | | |
| 11/15/2024 (Fri) | | New Albany 40-30 Itawamba AHS | | |
| 11/15/2024 (Fri) | | Poplarville 21-20 Columbia | | |
| 11/15/2024 (Fri) | | Quitman 55-27 Forrest County AHS | | |
| 3rd Round |
| 11/22/2024 (Fri) | | West Lauderdale 26-23 Shannon | | |
| 11/22/2024 (Fri) | | Louisville 39-7 New Albany | | |
| 11/22/2024 (Fri) | | Forest 17-12 Quitman | | |
| 11/22/2024 (Fri) | | Poplarville 42-21 McComb | | |
| Semi-finals |
| 11/29/2024 (Fri) | | Louisville 40-6 West Lauderdale | | |
| 11/29/2024 (Fri) | | Poplarville 24-21 Forest | | |
| Championship Game |
| 12/5/2024 (Thu) | | Poplarville 29-28 Louisville | | |
| 5A Playoffs |
| 1st Round |
| 11/15/2024 (Fri) | | West Point 41-0 Yazoo City | | |
| 11/15/2024 (Fri) | | Holmes County Central 20-7 Corinth | | |
| 11/15/2024 (Fri) | | Cleveland Central 31-13 Pontotoc | | |
| 11/15/2024 (Fri) | | Canton 50-41 New Hope | | |
| 11/15/2024 (Fri) | | Brookhaven 42-21 Vancleave | | |
| 11/15/2024 (Fri) | | Stone 17-14 Florence | | |
| 11/15/2024 (Fri) | | Gautier 36-30 Natchez | | |
| 11/15/2024 (Fri) | | Wayne County 42-14 South Jones | | |
| 2nd Round |
| 11/22/2024 (Fri) | | West Point 31-28 Holmes County Central | | |
| 11/22/2024 (Fri) | | Cleveland Central 27-26 Canton | | |
| 11/22/2024 (Fri) | | Brookhaven 33-7 Stone | | |
| 11/22/2024 (Fri) | | Gautier 28-27 Wayne County | | |
| Semi-finals |
| 11/29/2024 (Fri) | | West Point 14-7 Cleveland Central | | |
| 11/29/2024 (Fri) | | Gautier 37-35 Brookhaven | | |
| Championship Game |
| 12/8/2024 (Sun) | | West Point 28-21 Gautier | | |
| 6A Playoffs |
| 1st Round |
| 11/15/2024 (Fri) | | Grenada 35-0 Callaway | | |
| 11/15/2024 (Fri) | | Neshoba Central 28-22 Lake Cormorant | | |
| 11/15/2024 (Fri) | | Warren Central 43-0 Saltillo | | |
| 11/15/2024 (Fri) | | South Panola 34-27 Ridgeland | | |
| 11/15/2024 (Fri) | | Hattiesburg 48-14 Hancock | | |
| 11/15/2024 (Fri) | | Pascagoula 41-0 Terry | | |
| 11/15/2024 (Fri) | | Picayune 48-7 Pearl River Central | | |
| 11/15/2024 (Fri) | | George County 26-22 West Jones | | |
| 2nd Round |
| 11/22/2024 (Fri) | | Grenada 31-7 Neshoba Central | | |
| 11/22/2024 (Fri) | | Warren Central 21-3 South Panola | | |
| 11/22/2024 (Fri) | | Hattiesburg 33-17 Pascagoula | | |
| 11/22/2024 (Fri) | | Picayune 63-40 George County | | |
| Semi-finals |
| 11/29/2024 (Fri) | | Grenada 23-10 Warren Central | | |
| 11/29/2024 (Fri) | | Hattiesburg 39-35 Picayune | | |
| Championship Game |
| 12/8/2024 (Sun) | | Grenada 43-14 Hattiesburg | | |
| MAIS-1A Playoffs |
| 1st Round |
| 11/1/2024 (Fri) | | Tensas LA 62-36 Kemper Academy | | |
| 11/1/2024 (Fri) | | Marvell AR 70-62 Tallulah LA | | |
| 11/1/2024 (Fri) | | Riverdale LA 44-0 Union Christian LA | | |
| 11/1/2024 (Fri) | | Calhoun Academy 56-0 Franklin LA | | |
| 2nd Round |
| 11/8/2024 (Fri) | | Briarfield LA 54-0 Tensas LA | | |
| 11/8/2024 (Fri) | | Claiborne LA 52-16 Marvell AR | | |
| 11/8/2024 (Fri) | | Lee AR 64-22 Riverdale LA | | |
| 11/8/2024 (Fri) | | Wilkinson Christian 62-44 Calhoun Academy | | |
| Semi-finals |
| 11/15/2024 (Fri) | | Briarfield LA 38-16 Claiborne LA | | |
| 11/15/2024 (Fri) | | Wilkinson Christian 22-14 Lee AR | | |
| Championship Game |
| 11/22/2024 (Fri) | | Briarfield LA 32-18 Wilkinson Christian | | |
| MAIS-2A Playoffs |
| 1st Round |
| 11/1/2024 (Fri) | | Porters Chapel Academy 48-22 Park Place Christian | | |
| 11/1/2024 (Fri) | | Newton County Academy 55-18 Deer Creek | | |
| 11/1/2024 (Fri) | | Tunica Academy 20-0 Prentiss Christian | | |
| 11/1/2024 (Fri) | | Delta Academy 30-12 Christian Collegiate Academy | | |
| 2nd Round |
| 11/8/2024 (Fri) | | DeSoto AR 52-6 Porters Chapel Academy | | |
| 11/8/2024 (Fri) | | Newton County Academy 49-12 Bens Ford LA | | |
| 11/8/2024 (Fri) | | Tunica Academy 54-41 Prairie View LA | | |
| 11/8/2024 (Fri) | | Humphreys Academy 40-16 Delta Academy | | |
| Semi-finals |
| 11/15/2024 (Fri) | | DeSoto AR 40-30 Newton County Academy | | |
| 11/15/2024 (Fri) | | Tunica Academy 26-24 Humphreys Academy | | |
| Championship Game |
| 11/21/2024 (Thu) | | DeSoto AR 58-32 Tunica Academy | | |
| MAIS-3A Playoffs |
| 1st Round |
| 11/1/2024 (Fri) | | Winona Christian 42-21 Indianola Academy | | |
| 11/1/2024 (Fri) | | Greenville Christian 36-0 Manchester Academy | | |
| 11/1/2024 (Fri) | | North Delta 35-0 Carroll Academy | | |
| 11/1/2024 (Fri) | | Saint Joseph Greenville 42-0 Central Holmes Christian | | |
| 2nd Round |
| 11/8/2024 (Fri) | | Riverfield LA 36-7 Winona Christian | | |
| 11/8/2024 (Fri) | | Marshall Academy 28-26 Greenville Christian | | |
| 11/8/2024 (Fri) | | Kirk Academy 35-16 North Delta | | |
| 11/8/2024 (Fri) | | Saint Joseph Greenville 22-14 Canton Academy | | |
| Semi-finals |
| 11/15/2024 (Fri) | | Marshall Academy 22-12 Riverfield LA | | |
| 11/15/2024 (Fri) | | Kirk Academy 34-30 Saint Joseph Greenville | | |
| Championship Game |
| 11/21/2024 (Thu) | | Kirk Academy 35-10 Marshall Academy | | |
| MAIS-4A Playoffs |
| 1st Round |
| 11/1/2024 (Fri) | | Centreville Academy 34-7 Washington Academy | | |
| 11/1/2024 (Fri) | | Columbia Academy 43-8 Clinton Christian | | |
| 11/1/2024 (Fri) | | St. Aloysius 33-27 Winston Academy | | |
| 11/1/2024 (Fri) | | Wayne Academy 37-21 Amite | | |
| 2nd Round |
| 11/8/2024 (Fri) | | Tri-County Academy 35-14 Centreville Academy | | |
| 11/8/2024 (Fri) | | Columbia Academy 27-21 Central Hinds Academy | | |
| 11/8/2024 (Fri) | | Bowling Green LA 34-6 Saint Aloysius | | |
| 11/8/2024 (Fri) | | Wayne Academy 27-20 Lee Academy | | |
| Semi-finals |
| 11/15/2024 (Fri) | | Tri-County Academy 21-7 Columbia Academy | | |
| 11/15/2024 (Fri) | | Bowling Green LA 14-10 Wayne Academy | | |
| Championship Game |
| 11/22/2024 (Fri) | | Tri-County Academy 27-3 Bowling Green LA | | |
| MAIS-5A Playoffs |
| 1st Round |
| 11/1/2024 (Fri) | | Silliman LA 22-21 Bayou Academy | | |
| 11/1/2024 (Fri) | | Copiah Academy 36-7 Starkville Academy | | |
| 11/1/2024 (Fri) | | Lamar 21-20 Adams Christian | | |
| 11/1/2024 (Fri) | | Simpson Academy 47-21 Heritage Academy | | |
| 2nd Round |
| 11/8/2024 (Fri) | | Parklane Academy 42-12 Silliman LA | | |
| 11/8/2024 (Fri) | | Copiah Academy 37-36 Oak Forest LA | | |
| 11/8/2024 (Fri) | | Magnolia Heights 31-21 Lamar | | |
| 11/8/2024 (Fri) | | Leake Academy 45-36 Simpson Academy | | |
| Semi-finals |
| 11/15/2024 (Fri) | | Parklane Academy 17-10 Copiah Academy | | |
| 11/15/2024 (Fri) | | Leake Academy 28-23 Magnolia Heights | | |
| Championship Game |
| 11/22/2024 (Fri) | | Parklane Academy 70-42 Leake Academy | | |
